In a devastated future, humanity's only defense against the monstrous klaxosaurs are the children who pilot the robots known as Franxx. Failed Franxx pilot Hiro meets a mysterious horned girl just before his classmates' enlistment ceremony, and she doesn't care about his reputation. With no memory of piloting Strelizia, Hiro moves into the parasite dormitory. His classmates aren't thrilled to see him or Zero Two. After the test fails, Hiro wants to pilot with Zero Two again.

Zero Two is an artificially-created life form and elite pilot with an infamous reputation as the "Partner Killer" who aspires to become fully human. She is well known for addressing Hiro , the protagonist, by the eponymous term " darling ". Zero Two is considered one of the most popular characters of Darling in the Franxx and her personality has been well received by both fans and critics, with the latter typically citing her as one of the best aspects of the series. Zero Two had the most labor-intensive design process and was designed to be an iconic character to act as a flagship for Darling in the Franxx. Tanaka explained that the design team was more concentrated on "what sort of existence Zero Two had", rather than her appearance, beginning with a vague image of a "badass transfer student".

Darling in the Franxx is set in a dystopian future where youth are artificially created and indoctrinated solely to defend the remnants of civilization. The story follows a squad of ten pilots, particularly focusing on the partnership between Hiro, an esteemed former prodigy, and Zero Two, a hybrid human and elite pilot who aspires to become entirely human. The series features symbolism relating to the mythological Jian , an imperfect bird with only one eye and wing and thus may only fly when paired with another. The animation began international distribution simultaneously upon its domestic release. The streaming service Crunchyroll internationally simulcast the series, with Aniplus Asia simulcasting the series to Southeast Asia.

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